Psilocybin clinical trials you can apply to
103 trials recruiting now and 31 not yet recruiting, in 20 countries, from the ClinicalTrials.gov registry as of 28 October 2026. A trial is the free route to psilocybin with medical screening and support, if you qualify.
By condition
- Depression (44)
- PTSD (13)
- Anxiety (7)
- Alcohol use disorder (6)
- Opioid use disorder (7)
- Substance use (any) (22)
- Cancer and end-of-life distress (10)
- OCD (4)
- Pain and headache (12)
- Dementia and cognition (5)
- Healthy volunteers (15)
By US state
- California (16)
- New York (14)
- Maryland (18)
- Texas (8)
- Connecticut (8)
- Alabama (5)
- Colorado (5)
- Florida (2)
- Minnesota (4)
- Pennsylvania (5)
- Arizona (4)
- Georgia (3)
- Massachusetts (4)
- Wisconsin (4)
- Louisiana (2)
- New Mexico (2)
- Ohio (3)
- Washington (2)
Trials
134 of 134 trials
- RecruitingPhase 1NCT03289949
The Neurobiological Effect of 5-HT2AR Modulation
Basic Science · Gitte Moos Knudsen · Ages 18+
Copenhagen, Denmark
- RecruitingEarly phase 1NCT04123314
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Depressive Symptoms, Depression, Alzheimer Disease · Johns Hopkins University · Ages 18 to 85
Baltimore, Maryland, United States
- RecruitingPhase 1NCT04161066
Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine
Opioid Use Disorder · University of Wisconsin, Madison · Ages 21 to 65
Madison, Wisconsin, United States
- RecruitingPhase 2NCT04882839
Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD
Obsessive-compulsive Disorder · Beersheva Mental Health Center · Ages 18 to 65
Beersheba, Israel
- RecruitingEarly phase 1NCT05068791
Psilocybin-facilitated Treatment for Chronic Pain
Fibromyalgia, Primary · University of Alabama at Birmingham · Ages 25 to 65
Birmingham, Alabama, United States
- RecruitingPhase 1NCT05265546
Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Perception Disorders · University of California, Berkeley · Ages 21+
Berkeley, California, United States
- RecruitingPhase 1 / Phase 2NCT05301608
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Healthy · Johns Hopkins University · Ages 18 to 75
Baltimore, Maryland, United States
- RecruitingPhase 2 / Phase 3NCT05398484
Psilocybin Therapy in Advanced Cancer
Advanced Cancer · NYU Langone Health · Ages 21 to 100
2 sites in United States (Aurora, New York)
- RecruitingPhase 2NCT05403086
Pragmatic Trial of Psilocybin Therapy in Palliative Care
Demoralization · Charles S. Grob, M.D. · Ages 18+
5 sites in United States
- RecruitingPhase 2NCT05452772
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
Tobacco Use Disorder · Johns Hopkins University · Ages 21+
3 sites in United States (Birmingham, Baltimore, New York)
- RecruitingPhase 2NCT05585229
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
Opioid Dependence, Chronic Pain · University of British Columbia · Ages 19 to 75
Kelowna, British Columbia, Canada
- RecruitingPhase 1NCT05866471
The ENHANCE Study: taVNS and Psilocybin
Healthy, Psychedelic Experiences, Vagus Nerve Stimulation · University of Wisconsin, Madison · Ages 18 to 70
Madison, Wisconsin, United States
- RecruitingPhase 2NCT05995769
Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder
Alcohol Use Disorder, Alcoholism · University of Calgary · Ages 22 to 65
Calgary, Alberta, Canada
- RecruitingPhase 2NCT06067737
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
Opioid Use Disorder · Johns Hopkins University · Ages 21 to 70
Baltimore, Maryland, United States
- RecruitingPhase 2NCT06072898
A Randomized Neuroimaging Trial of Psilocybin in Depression
Depressive Disorder, Major Depressive Disorder · Sunnybrook Health Sciences Centre · Ages 18 to 64
Toronto, Ontario, Canada
- RecruitingPhase 2NCT06132178
Psilocybin rTMS for Treatment Resistant Depression
Treatment Resistant Depression, MDD, Major Depressive Disorder · University of Texas at Austin · Ages 22 to 65
Austin, Texas, United States
- RecruitingPhase 1NCT06160284
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Opioid Use Disorder · Yale University · Ages 25 to 55
New Haven, Connecticut, United States
- RecruitingPhase 2NCT06200155
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
Depression, Anxiety, Psilocybin-Assisted Psychotherapy, Advanced Cancer · M.D. Anderson Cancer Center · Ages 25+
Houston, Texas, United States
- RecruitingPhase 2NCT06233344
Mindfulness-Assisted Psychedelic Therapy
Mental Health · University of Southern California · Ages 25+
Los Angeles, California, United States
- RecruitingPhase 3NCT06247839
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
Major Depressive Disorder · Sharmin Ghaznavi · Ages 18 to 55
Charlestown, Massachusetts, United States
- RecruitingPhase 2NCT06319378
Cancer Related Major Depression Treated With a Single Dose of Psilocybin
MDD · Section for Affective Disorders; Northern Stockholm Psychiatry · Ages 20 to 80
4 sites in Sweden
- RecruitingPhase 2NCT06349083
Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD
Alcohol Use Disorder · NYU Langone Health · Ages 18 to 65
New York, New York, United States
- RecruitingPhase 1NCT06355414
Psilocybin in Chronic Low Back Pain and Depression
Chronic Low-back Pain, Depression · Johns Hopkins University · Ages 21 to 80
Baltimore, Maryland, United States
- RecruitingPhase 1NCT06367738
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
Aging · University of California, Berkeley · Ages 60 to 85
Berkeley, California, United States
- RecruitingPhase not statedNCT06368492
The Impact of Psilocybin on Pain in Fibromyalgia Patients
Fibromyalgia · Maastricht University · Ages 18 to 65
2 sites in Netherlands (Maastricht, Leiden)
- RecruitingPhase 2NCT06378229
Psilocybin for Hospitalized Patients with Treatment-resistant Depression
Treatment Resistant Depression · University Hospital, Ghent · Ages 18+
Ghent, Oost-Vlaanderen, Belgium
- RecruitingPhase 2NCT06399263
Study of Psilocybin for Anorexia in Young Adults
Anorexia Nervosa · Marissa Raymond-Flesch, MD, MPH · Ages 18 to 25
2 sites in United States (San Francisco)
- RecruitingPhase 2NCT06405607
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial
Alcohol Use Disorder, Alcohol Dependence, Alcohol Abuse · University of Iowa · Ages 21 to 65
Iowa City, Iowa, United States
- RecruitingPhase 1NCT06430541
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence
Breast Cancer, Ovarian Cancer · University of Colorado, Denver · Ages 21+
2 sites in United States (Aurora)
- RecruitingPhase 1NCT06442423
Open-Label Psilocybin Study in Transdiagnostic Population
Transdiagnostic, Depression - Major Depressive Disorder, Anxiety · Yale University · Ages 18+
New Haven, Connecticut, United States
- RecruitingPhase 2NCT06455293
Psilocybin Therapy for Depression in Parkinson's Disease
Parkinson Disease, Depression · Joshua Woolley, MD, PhD · Ages 40 to 80
San Francisco, California, United States
- RecruitingEarly phase 1NCT06464367
Mechanistic Studies of Psilocybin in Headache Disorders
Migraine · Yale University · Ages 21 to 70
West Haven, Connecticut, United States
- RecruitingPhase 2NCT06512194
Investigation to Understand and Optimize Psilocybin
Depression · Charles Raison · Ages 18 to 70
Edwards, Colorado, United States
- RecruitingPhase 2NCT06512220
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Treatment Resistant Depression · Centre for Addiction and Mental Health · Ages 18 to 65
Toronto, Ontario, Canada
- RecruitingPhase 2NCT06518720
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Treatment Resistant Depression, Chronic Pain · Centre for Addiction and Mental Health · Ages 18 to 65
Toronto, Ontario, Canada
- RecruitingPhase 2NCT06592833
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
Major Depressive Disorder · Icahn School of Medicine at Mount Sinai · Ages 21 to 80
New York, New York, United States
- RecruitingPhase 1NCT06615908
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
Persisting Symptoms After Concussion · University of Calgary · Ages 18 to 65
Calgary, Alberta, Canada
- RecruitingPhase 2NCT06626139
Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers
Healthy Participants With Lower-than-average Mental Well-being · Robin Carhart-Harris, PhD, MA · Ages 21 to 70
San Francisco, California, United States
- RecruitingEarly phase 1NCT06656702
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
- RecruitingPhase 1NCT06660381
Psilocybin-assisted Treatment for Cannabis Use Disorder
Cannabis Use Disorder · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
- RecruitingPhase 1NCT06692192
The RECAP2 Study: Midazolam and Psilocybin
Psilocybin · University of Wisconsin, Madison · Ages 18 to 65
Madison, Wisconsin, United States
- RecruitingPhase 2NCT06706232
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
Bipolar II Disorder, Depression, Bipolar, Suicidality · The University of Texas Health Science Center, Houston · Ages 25 to 70
Houston, Texas, United States
- RecruitingEarly phase 1NCT06724289
Psilocybin for Prolonged Grief Disorder
Prolonged Grief Disorder · University of Virginia · Ages 18 to 65
Charlottesville, Virginia, United States
- RecruitingPhase 2NCT06731335
Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN
Chronic Neuropathic Pain, Pain Management · Unity Health Toronto · Ages 18 to 65
2 sites in Canada (Toronto)
- Not yet recruitingEarly phase 1NCT06760533
Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)
IBS - Irritable Bowel Syndrome · NYU Langone Health · Ages 18 to 75
New York, New York, United States
- RecruitingPhase 2NCT06768944
Subjective Experience Following Psilocybin
Investigating the Importance of the Subjective Psychedelic Experience · University of Calgary · Ages 18 to 65
Calgary, Alberta, Canada
- RecruitingPhase 1NCT06772753
Investigation of Psychedelic Effects in Psychoactive Substances
Psychedelic Effects in Healthy Volunteers · Johns Hopkins University · Ages 25 to 55
Baltimore, Maryland, United States
- RecruitingPhase 2NCT06782724
Psilocybin Therapy for Psychological Distress in Palliative Patients
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis) · University Medical Center Groningen · Ages 18+
4 sites in 4 countries
- RecruitingPhase 2NCT06786325
Wellcome Leap Psilocybin for OUD
Opioid Use Disorder · Anna Rose Childress, Ph.D. · Ages 18 to 60
Philadelphia, Pennsylvania, United States
- RecruitingPhase 3NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder · Cybin IRL Limited · Ages 18 to 85
79 sites in 8 countries
- RecruitingPhase 2NCT06796062
Psilocybin for Opioid Use Disorder (OUD)
Opioid Use Disorder · NYU Langone Health · Ages 18 to 65
5 sites in United States
- RecruitingPhase 1NCT06796361
Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness
Healthy · University Hospital, Basel, Switzerland · Ages 25 to 75
Basel, Canton of Basel-City, Switzerland
- RecruitingEarly phase 1NCT06798636
PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm
Self Harm · Imperial College London · Ages 16 to 25
London, United Kingdom
- RecruitingPhase 2NCT06801041
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
Depression, Anxiety, Cancer · M.D. Anderson Cancer Center · Ages 18+
Houston, Texas, United States
- RecruitingPhase 2NCT06810310
Psilocybin on Brain Mechanisms of Motivation in OUD
Opioid Use Disorder · University of Pennsylvania · Ages 18 to 60
Philadelphia, Pennsylvania, United States
- RecruitingPhase 1 / Phase 2NCT06814522
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
Burnout, Burnout, Healthcare Workers · University of California, San Diego · Ages 21 to 70
San Diego, California, United States
- RecruitingPhase 1NCT06815653
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
Healthy · University College, London · Ages 21 to 65
London, United Kingdom
- RecruitingPhase 1NCT06818994
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer
Demoralization, Safety · Gustavo Vazquez · Ages 18 to 70
Kingston, Ontario, Canada
- RecruitingPhase 2NCT06820723
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
Depression, Anxiety, Major Depressive Disorder · Ohio State University · Ages 21 to 65
Columbus, Ohio, United States
- Not yet recruitingPhase 2NCT06827054
Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm · Roswell Park Cancer Institute · Ages 18 to 75
Buffalo, New York, United States
- Not yet recruitingPhase 2NCT06885996
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV) · University of Calgary · Ages 18 to 65
2 sites in Canada (Calgary, Kelowna)
- RecruitingPhase 2NCT06888128
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma
PTSD · Baylor College of Medicine · Ages 21 to 64
Houston, Texas, United States
- RecruitingPhase 1 / Phase 2NCT06898606
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
Depressive Disorder · Federal University of Latin American Integration · Ages 25 to 65
Foz do Iguaçu, Paraná, Brazil
- RecruitingPhase 2NCT06899165
Psilocybin-Assisted Therapy for Intergenerational Trauma
Psychological Stress, Depression, Anxiety · Rachel Yehuda · Ages 18+
New York, New York, United States
- RecruitingPhase 1NCT06899334
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
Healthy · University Hospital, Basel, Switzerland · Ages 25+
Basel, Switzerland
- RecruitingEarly phase 1NCT06899594
Psilocybin for Methamphetamine Addiction
Methamphetamine Use Disorder · Kevin Murnane · Ages 25 to 65
Shreveport, Louisiana, United States
- RecruitingPhase 2NCT06902974
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD
Post Traumatic Stress Disorder, PTSD · Sunstone Medical · Ages 18+
Rockville, Maryland, United States
- RecruitingPhase 2NCT06943573
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder
Bipolar II Depression · Lakshmi N Yatham · Ages 19 to 65
3 sites in Canada (Vancouver, Ottawa, Toronto)
- RecruitingPhase 2NCT06969170
Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) · Claudio N Soares · Ages 18 to 60
Kingston, Ontario, Canada
- RecruitingPhase 1NCT06988319
Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study
Chronic Pelvic Pain · Oregon Health and Science University · Ages 18 to 45
Portland, Oregon, United States
- RecruitingPhase 1NCT06989957
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder · Johns Hopkins University · Ages 21+
Baltimore, Maryland, United States
- Not yet recruitingPhase 1 / Phase 2NCT06992999
Psilocybin for Treatment of OCD-2
Obsessive - Compulsive Disorder · Francisco A Moreno · Ages 18+
Tucson, Arizona, United States
- RecruitingPhase 2NCT07048743
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced Cancer
Caregiver Distress · University Health Network, Toronto · Ages 18+
Toronto, Ontario, Canada
- RecruitingPhase 1NCT07053917
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
Stroke, Chronic Stroke, Intracerebral Haemorrhage · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
- RecruitingPhase 3NCT07063862
Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)
Psychological Distress · Bruyère Health Research Institute. · Ages 18+
7 sites in Canada
- RecruitingPhase 2NCT07072728
Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder
Adjustment Disorder, Adjustment Disorder With Anxious Mood, Cancer · Psyence Australia Pty Ltd · Ages 18 to 80
3 sites in Australia (Abbotsford, Northcote, Leederville)
- Not yet recruitingPhase 1 / Phase 2NCT07079852
The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function
Healthy · Manoj Doss · Ages 21 to 45
Austin, Texas, United States
- RecruitingPhase 1NCT07079930
Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers
Healthy Volunteers · Hadassah Medical Organization · Ages 25 to 60
Jerusalem, Israel
- RecruitingPhase 2NCT07104916
Mindfulness-based Psilocybin Therapy for PTSD
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder · Anthony P King · Ages 21 to 65
Columbus, Ohio, United States
- RecruitingEarly phase 1NCT07118332
Psilocybin as a Treatment for Chronic Pain in Smokers
Smokers With Chronic Pain · Yale University · Ages 21 to 65
2 sites in United States (West Haven)
- RecruitingPhase 2NCT07169747
Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia Nervosa
Anorexia Nervosa · Region Skane · Ages 16 to 35
Lund, Sweden
- RecruitingPhase 1NCT07180108
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Psilocybin, Music Intervention · Johns Hopkins University · Ages 21 to 75
Baltimore, Maryland, United States
- RecruitingPhase 2NCT07183748
Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression
Treatment Resistant Depression · Beersheva Mental Health Center · Ages 18 to 65
Beersheba, Israel
- RecruitingPhase 2NCT07210112
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)
Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD) · Centre Hospitalier St Anne · Ages 18+
Paris, France
- RecruitingPhase 2NCT07211438
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
Treatment-Resistant Depression · Centre for Addiction and Mental Health · Ages 18 to 70
2 sites in Canada (Toronto)
- RecruitingPhase 2NCT07216404
Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer
Lung Non-Small Cell Carcinoma, Unipolar Depression · Alan Davis · Ages 18+
Columbus, Ohio, United States
- RecruitingPhase 3NCT07226232
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
Major Depression · VA Office of Research and Development · Ages 18 to 75
5 sites in United States
- Not yet recruitingPhase 2NCT07227909
NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy
Psilocybin, Neuropathy · M.D. Anderson Cancer Center · Ages 18+
Houston, Texas, United States
- RecruitingPhase 1 / Phase 2NCT07251491
Psilocybin to Treat Depression in Spinal Cord Injury
Spinal Cord Injury, Depression - Major Depressive Disorder, Veteran · James J. Peters Veterans Affairs Medical Center · Ages 22+
The Bronx, New York, United States
- RecruitingPhase 1 / Phase 2NCT07281352
RCT of Psilocybin-assisted CBT for Depression
Major Depressive Diorder · University of California, Los Angeles · Ages 21 to 60
Los Angeles, California, United States
- Not yet recruitingPhase 2NCT07296094
Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder
Alcohol Use Disorder · Brigham and Women's Hospital · Ages 18 to 65
Boston, Massachusetts, United States
- Not yet recruitingPhase 2NCT07296328
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
Stuttering · NYU Langone Health · Ages 18 to 50
New York, New York, United States
- Not yet recruitingPhase 2NCT07306364
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin · Yale University · Ages 21 to 65
New Haven, Connecticut, United States
- RecruitingPhase 2NCT07332143
Psilocybin-Assisted Therapy
PTSD · Emory University · Ages 18+
Atlanta, Georgia, United States
- RecruitingPhase 1NCT07347405
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
Obsessive-Compulsive Disorder · Francisco A Moreno · Ages 18+
Tucson, Arizona, United States
- Not yet recruitingPhase 1NCT07360301
Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study
Well-Being, Psychological, Psychedelic Experiences · University of Wisconsin, Madison · Ages 18 to 45
Madison, Wisconsin, United States
- Not yet recruitingPhase 2NCT07373535
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
Treatment-Resistant Major Depressive Disorder · Kyle Greenway · Ages 21+
2 sites in Canada (Montreal)
- RecruitingPhase 1NCT07386730
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Anhedonia in Healthy Volunteers, Older Adults (50-90 Years) · Jennifer Mitchell · Ages 50 to 85
San Francisco, California, United States
- RecruitingPhase 2NCT07391332
Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study
Gambling Disorder · Nantes University Hospital · Ages 18+
Nantes, France
- RecruitingPhase 2NCT07405606
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD) · Centre for Addiction and Mental Health · Ages 18 to 65
Toronto, Ontario, Canada
- Not yet recruitingPhase 1NCT07406828
Psilocybin After Trauma Surgery for Pain
Pain Management, Postoperative Pain · Trent Emerick · Ages 25 to 65
Pittsburgh, Pennsylvania, United States
- Not yet recruitingPhase 1NCT07433452
The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.
Healthy Participants, Placebo - Control, Psilocybin · Gabriella Gobbi · Ages 21 to 65
Sites not yet listed
- Not yet recruitingPhase 2NCT07479550
Study of Psilocybin Under Anesthesia Controlled by EEG
Major Depression · Stanford University · Ages 25 to 65
Stanford, California, United States
- RecruitingPhase 1NCT07490353
Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects
Depression - Major Depressive Disorder, Anhedonia · Medical University of Vienna · Ages 18 to 55
Vienna, State of Vienna, Austria
- Not yet recruitingPhase 1 / Phase 2NCT07499583
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
Treatment Resistant Depression, Substance Use Disorders · Indiana University · Ages 18+
2 sites in United States (Indianapolis)
- RecruitingPhase 1NCT07506395
Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder
PTSD · University of New Mexico · Ages 18 to 89
Albuquerque, New Mexico, United States
- RecruitingPhase 1NCT07516405
Safety and Tolerability Trial of Psilocybin in Healthy Older Adults
Healthy Volunteer, Older Adults (65-85 Years) · University of Colorado, Denver · Ages 65 to 85
6 sites in United States
- RecruitingEarly phase 1NCT07565493
Psilocybin Administration With 5-HT1a Blockade
Psychedelic Effects in Healthy Volunteers · Johns Hopkins University · Ages 21 to 60
Baltimore, Maryland, United States
- Not yet recruitingPhase 2NCT07565909
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
Depression, Anxiety · University of Washington · Ages 25 to 70
Sites not yet listed
- Not yet recruitingPhase 2NCT07566104
Group PACBT for Depression
Depression - Major Depressive Disorder, Psilocybin, Cognitive Behavioral Therapy · University of California, Los Angeles · Ages 21 to 60
Los Angeles, California, United States
- RecruitingPhase 2 / Phase 3NCT07570654
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms · COMPASS Pathways · Ages 18+
10 sites in 2 countries
- Not yet recruitingPhase 2NCT07582120
Psilocybin-Assisted Therapy as a Treatment for Depression
Depression · Washington University School of Medicine · Ages 18+
St Louis, Missouri, United States
- RecruitingPhase 1NCT07607938
Psilocybin as a Novel Therapy for Residual Anhedonia
Anhedonia, Emotional Blunting · NYU Langone Health · Ages 18 to 65
New York, New York, United States
- RecruitingPhase 1 / Phase 2NCT07610135
Psilocybin Efficacy With or Without Pimavanserin Pretreatment
Mood (Psychological Function), Well Being, Mood · Johns Hopkins University · Ages 21 to 65
Baltimore, Maryland, United States
- RecruitingPhase 2NCT07610369
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
Depression, Parkinson's Disease (PD) · Yale University · Ages 40 to 80
New Haven, Connecticut, United States
- RecruitingPhase 3NCT07638553
Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms
Alcohol Use Disorder, Depressive Sympotoms, Psilocybin · Centre Hospitalier Universitaire de Nīmes · Ages 18+
8 sites in France
- Not yet recruitingPhase 1NCT07693153
The Effects of Psilocybin on Social Connectedness
Loneliness, Grief · Yale University · Ages 21 to 65
New Haven, Connecticut, United States
- RecruitingPhase 3NCT07703722
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD) · Khyber Medical University Peshawar · Ages 18 to 60
3 sites in Pakistan (Islamabad, Peshawar)
- Not yet recruitingPhase 1NCT07719088
Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
Aging, Longevity, Biomarkers of Aging · Charles Raison · Ages 60 to 80
Edwards, Colorado, United States
- RecruitingPhase 2NCT07721467
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Alzheimer's Disease · National Institute on Aging (NIA) · Ages 65 to 120
Baltimore, Maryland, United States
- RecruitingEarly phase 1NCT07732166
Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.
Healthy Adults · Pontifícia Universidade Católica do Rio de Janeiro · Ages 21 to 60
Rio de Janeiro, Rio de Janeiro, Brazil
- RecruitingEarly phase 1NCT07737054
Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD
Post-Traumatic Stress Disorder, PTSD · Tel-Aviv Sourasky Medical Center · Ages 21 to 65
Tel Aviv, Israel
- Not yet recruitingPhase 2NCT07745569
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression · University of New Mexico · Ages 18 to 69
Sites not yet listed
- Not yet recruitingPhase 2NCT07756736
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV) · Nicky Mehtani, MD, MPH · Ages 25 to 64
San Francisco, California, United States
- Not yet recruitingPhase 2NCT07774702
Psilocybin for Methamphetamine Use Disorder
Methamphetamine Use Disorder · Peter Hendricks · Ages 18+
Birmingham, Alabama, United States
- Not yet recruitingPhase 2NCT07791901
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
Advanced Cancer, Demoralization, Existential Distress · University of Calgary · Ages 18+
2 sites in Canada (Calgary, Kingston)
- Not yet recruitingPhase 2NCT07792538
Psilocybin-Assisted Psychotherapy for Veterans With PTSD
Posttraumatic Stress Disorder (PTSD) · ARQ National Psychotrauma Centre · Ages 18 to 70
Oegstgeest, Netherlands
- RecruitingPhase 1NCT07818564
Pilot Study on the Effects of Psilocybin on Belief Updating and Insight Formation
Phase I · Brown University · Ages 18+
Providence, Rhode Island, United States
- Not yet recruitingPhase 1NCT07818720
MLS101 Study in PMDD
Premenstrual Dysphoric Disorder ( PMDD), PMDD · MycoMedica Life Sciences PBC · Ages 18 to 50
Sites not yet listed
- Not yet recruitingPhase 2NCT07820033
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial
Advanced Cancer, Stage IV Solid Tumor Cancer, Stage IV Sarcoma of Bone · University Health Network, Toronto · Ages 18+
Toronto, Ontario, Canada
- Not yet recruitingPhase 1NCT07833761
ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder
Borderline Personality Disorder, Borderline Personality Pathology, Depressive Symptoms · University of Minnesota · Ages 25 to 65
2 sites in United States (Minneapolis, Saint Louis Park)
- Not yet recruitingPhase 2NCT07852832
Effects of Psilocybin on Craving in Nicotine Dependence
Nicotine Dependence · University of British Columbia · Ages 20 to 35
Sites not yet listed
- Not yet recruitingPhase 1NCT07877987
The Impact of Dose on the Impairing, Intoxicating, and Abuse-Related Effects of Psilocybin
Psilocybin Intoxication · Johns Hopkins University · Ages 21+
Baltimore, Maryland, United States
- Not yet recruitingPhase 2NCT07895134
Psilocybin for Depression in Veterans
Major Depression · VA Office of Research and Development · Ages 18 to 70
4 sites in United States
How joining a trial works
- Free to take part
- Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.
- Screened first
- Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.
- Eligibility is strict
- Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.
- You may get a placebo
- Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.
- Contact the study team through the registry
- Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.
- Not medical advice
- This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.
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