Psilocybin clinical trials in Pennsylvania
5 trials with 6 study sites in Pennsylvania, recruiting or not yet recruiting, read from ClinicalTrials.gov on 28 October 2026. The site in Pennsylvania is named under each trial.
- RecruitingPhase 2NCT06786325
Wellcome Leap Psilocybin for OUD
Opioid Use Disorder · Anna Rose Childress, Ph.D. · Ages 18 to 60
Philadelphia, Pennsylvania, United States
In Pennsylvania: University of Pennsylvania, Philadelphia
- RecruitingPhase 3NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder · Cybin IRL Limited · Ages 18 to 85
79 sites in 8 countries
In Pennsylvania: Adams Clinical Philadelphia, Philadelphia; Flourish Research Philadelphia, Philadelphia
- RecruitingPhase 2NCT06810310
Psilocybin on Brain Mechanisms of Motivation in OUD
Opioid Use Disorder · University of Pennsylvania · Ages 18 to 60
Philadelphia, Pennsylvania, United States
In Pennsylvania: University of Pennsylvania, Philadelphia
- RecruitingPhase 3NCT07226232
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
Major Depression · VA Office of Research and Development · Ages 18 to 75
5 sites in United States
In Pennsylvania: Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
- Not yet recruitingPhase 1NCT07406828
Psilocybin After Trauma Surgery for Pain
Pain Management, Postoperative Pain · Trent Emerick · Ages 25 to 65
Pittsburgh, Pennsylvania, United States
In Pennsylvania: UPMC Presbyterian, Pittsburgh
How joining a trial works
- Free to take part
- Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.
- Screened first
- Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.
- Eligibility is strict
- Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.
- You may get a placebo
- Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.
- Contact the study team through the registry
- Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.
- Not medical advice
- This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.