Psilocybin clinical trials in California
16 trials with 29 study sites in California, recruiting or not yet recruiting, read from ClinicalTrials.gov on 28 October 2026. The site in California is named under each trial.
- RecruitingPhase 1NCT05265546
Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Perception Disorders · University of California, Berkeley · Ages 21+
Berkeley, California, United States
In California: University of California, Berkeley, Berkeley
- RecruitingPhase 2NCT05403086
Pragmatic Trial of Psilocybin Therapy in Palliative Care
Demoralization · Charles S. Grob, M.D. · Ages 18+
5 sites in United States
In California: Marin Cancer Care, Greenbrae; University of California, Los Angeles, Los Angeles; University of San Francisco, San Francisco; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
- RecruitingPhase 2NCT06233344
Mindfulness-Assisted Psychedelic Therapy
Mental Health · University of Southern California · Ages 25+
Los Angeles, California, United States
In California: Univeristy of Southern California Brain and Creativity Institute, Los Angeles
- RecruitingPhase 1NCT06367738
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
Aging · University of California, Berkeley · Ages 60 to 85
Berkeley, California, United States
In California: University of California, Berkeley, Berkeley
- RecruitingPhase 2NCT06399263
Study of Psilocybin for Anorexia in Young Adults
Anorexia Nervosa · Marissa Raymond-Flesch, MD, MPH · Ages 18 to 25
2 sites in United States (San Francisco)
In California: University of California, San Francisco, San Francisco; University of California, San Francisco, San Francisco
- RecruitingPhase 2NCT06455293
Psilocybin Therapy for Depression in Parkinson's Disease
Parkinson Disease, Depression · Joshua Woolley, MD, PhD · Ages 40 to 80
San Francisco, California, United States
In California: University of California, San Francisco, San Francisco
- RecruitingPhase 2NCT06626139
Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers
Healthy Participants With Lower-than-average Mental Well-being · Robin Carhart-Harris, PhD, MA · Ages 21 to 70
San Francisco, California, United States
In California: UCSF Mission Bay, San Francisco
- RecruitingPhase 3NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder · Cybin IRL Limited · Ages 18 to 85
79 sites in 8 countries
In California: Behavioral Research Specialists, LLC, Glendale; Sun Valley Research Center, Imperial; CalNeuro Research Group, Los Angeles; Lipov Medical Group, Los Angeles; ATP Clinical Research, Orange; NRC Research Institute, Orange; Inland Psychiatric Medical Group Inc (IPMG Research), San Juan Capistrano; Psychedelic Science Institute, Santa Monica; Stanford University, Stanford
- RecruitingPhase 1 / Phase 2NCT06814522
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
Burnout, Burnout, Healthcare Workers · University of California, San Diego · Ages 21 to 70
San Diego, California, United States
In California: UC San Diego, San Diego
- RecruitingPhase 1 / Phase 2NCT07281352
RCT of Psilocybin-assisted CBT for Depression
Major Depressive Diorder · University of California, Los Angeles · Ages 21 to 60
Los Angeles, California, United States
In California: UCLA Semel Institute, Los Angeles
- RecruitingPhase 1NCT07386730
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Anhedonia in Healthy Volunteers, Older Adults (50-90 Years) · Jennifer Mitchell · Ages 50 to 85
San Francisco, California, United States
In California: University of California San Francisco, Sandler Neuroscience Building, San Francisco
- RecruitingPhase 1NCT07516405
Safety and Tolerability Trial of Psilocybin in Healthy Older Adults
Healthy Volunteer, Older Adults (65-85 Years) · University of Colorado, Denver · Ages 65 to 85
6 sites in United States
In California: University of California San Francisco (UCSF) Department of Neurology, San Francisco
- Not yet recruitingPhase 2NCT07479550
Study of Psilocybin Under Anesthesia Controlled by EEG
Major Depression · Stanford University · Ages 25 to 65
Stanford, California, United States
In California: Stanford University, Stanford
- Not yet recruitingPhase 2NCT07566104
Group PACBT for Depression
Depression - Major Depressive Disorder, Psilocybin, Cognitive Behavioral Therapy · University of California, Los Angeles · Ages 21 to 60
Los Angeles, California, United States
In California: UCLA Semel Institute, Los Angeles
- Not yet recruitingPhase 2NCT07756736
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV) · Nicky Mehtani, MD, MPH · Ages 25 to 64
San Francisco, California, United States
In California: UCSF at Zuckerberg San Francisco General Hospital, San Francisco
- Not yet recruitingPhase 2NCT07895134
Psilocybin for Depression in Veterans
Major Depression · VA Office of Research and Development · Ages 18 to 70
4 sites in United States
In California: VA San Diego Healthcare System, San Diego, CA, San Diego; San Francisco VA Medical Center, San Francisco, CA, San Francisco
How joining a trial works
- Free to take part
- Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.
- Screened first
- Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.
- Eligibility is strict
- Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.
- You may get a placebo
- Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.
- Contact the study team through the registry
- Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.
- Not medical advice
- This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.