Psilocybin tolerance calculator
An approximate estimate of remaining tolerance from days since your last dose, with the research on how fast tolerance builds and fades.
An approximation, labelled as one
Research establishes that tolerance to psilocybin is strong and that it crosses over to LSD. It does not give a day-by-day recovery curve. The curve below is our illustration, set so that it never suggests less than two weeks for a full reset. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
An illustrative curve, not a measurement. We found no study that measured how fast tolerance fades after a single dose.
Estimate, not a measurement
Partial tolerance likely
About 27% on the illustrative curve, where 100 is the peak after a high dose.
Suggested wait: about 9 more days. We use two weeks after the last dose as a deliberately conservative default, not a measured figure; the illustrative curve for a moderate dose drops below the line at about day 13.
Effects may still be noticeably blunted. Waiting is the only reliable way to reset; a bigger dose is not.
Tolerance crosses over: a recent dose of LSD or another classic psychedelic counts as well.
The illustrative curve, in full
The same estimate for every dose size and day, so the page works without JavaScript. Percentages are positions on our illustrative curve, not measurements.
| Last dose | Day 1 | Day 3 | Day 5 | Day 7 | Day 10 | Day 14 |
|---|---|---|---|---|---|---|
| Microdose | 35%Partial tolerance likely | 20%Partial tolerance likely | 11%Mostly faded | 6%Mostly faded | 3%Mostly faded | 1%Likely reset |
| Low | 60%Strong tolerance likely | 34%Partial tolerance likely | 19%Partial tolerance likely | 11%Mostly faded | 5%Mostly faded | 1%Likely reset |
| Moderate | 85%Strong tolerance likely | 48%Strong tolerance likely | 27%Partial tolerance likely | 15%Partial tolerance likely | 6%Mostly faded | 2%Likely reset |
| High | 100%Strong tolerance likely | 56%Strong tolerance likely | 32%Partial tolerance likely | 18%Partial tolerance likely | 8%Mostly faded | 2%Likely reset |
What the research does say
- Tolerance is strong. A review for the US drug scheduling process states that tolerance to the psychological and physiological effects of psilocybin is strong. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
- It builds fast. The same review quotes a pharmacology textbook: tolerance to the behavioural effects of LSD develops after three or four daily doses. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
- It crosses over. In a 1961 study of repeated dosing, people tolerant to LSD were largely tolerant to psilocybin as well, and the reverse. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026] Count a recent LSD or other classic psychedelic experience as if it were mushrooms.
- No withdrawal. Physical dependence and withdrawal have not been documented. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
What it does not say
We found no study that measured how many days tolerance takes to fade after a single dose of psilocybin, at any dose. Figures of a few days, one week or two weeks circulate widely without a measured source. We chose two weeks because waiting longer has no safety cost, and because it leaves time to integrate one experience before the next.
Why not take more?
Partial tolerance fades unevenly, and potency differs between batches. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026] Adding grams to beat tolerance stacks two unknowns. Use the dose calculator's cautious figure, and wait.
Questions
How long does psilocybin tolerance last?
Nobody has measured it precisely for single doses. Research shows tolerance to psilocybin is strong and develops with repeated doses, but we found no study that measured how many days it takes to fade. This calculator uses two weeks as a deliberately conservative default. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
Does LSD tolerance carry over to mushrooms?
Yes. A 1961 study found people tolerant to LSD were largely cross-tolerant to psilocybin, and the reverse, and later reviews confirm the cross-tolerance. [The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Neuropharmacology, 2018, read 28 October 2026]
Can I take more mushrooms to get past tolerance?
Do not. Tolerance is unpredictable as it fades, and a larger dose taken against partial tolerance can land far harder than expected. Waiting is the only reliable reset.
Does microdosing build tolerance?
Possibly. Microdosing schedules build in days off for this reason. The Fadiman protocol takes a microdose every third day. [Might microdosing psychedelics be safe and beneficial? An initial exploration, Journal of Psychoactive Drugs, 2019, read 28 October 2026]
When a retreat or licensed centre is the better choice
If you take any medication on the interaction checker, have a personal or family history of psychosis or bipolar disorder, have a heart condition, or have nobody sober and steady to sit with you, a setting with screening and trained staff is the safer choice. In trials, participants were screened first and supported by trained monitors throughout. [Human hallucinogen research: guidelines for safety, Journal of Psychopharmacology, 2008, read 28 October 2026]
- All retreats and licensed centres, with prices and the law in each place
- Find your retreat: seven questions and a shortlist
- Licensed sessions in Oregon or Colorado, or retreats in the Netherlands and Jamaica
If you need help now
- 988 Suicide & Crisis Lifeline (US): call or text 988, any hour. 988lifeline.org
- Fireside Project (US): a psychedelic peer support line, call or text 62-FIRESIDE (623-473-7433). [Fireside Project: psychedelic peer support line, Fireside Project, read 28 October 2026]
- A medical emergency anywhere: call your local emergency number (911 in the US, 112 in the EU).