Psilocybin clinical trials in Maryland
18 trials with 19 study sites in Maryland, recruiting or not yet recruiting, read from ClinicalTrials.gov on 28 October 2026. The site in Maryland is named under each trial.
- RecruitingEarly phase 1NCT04123314
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Depressive Symptoms, Depression, Alzheimer Disease · Johns Hopkins University · Ages 18 to 85
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 1 / Phase 2NCT05301608
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Healthy · Johns Hopkins University · Ages 18 to 75
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 2NCT05403086
Pragmatic Trial of Psilocybin Therapy in Palliative Care
Demoralization · Charles S. Grob, M.D. · Ages 18+
5 sites in United States
In Maryland: Sunstone Therapies, Rockville
- RecruitingPhase 2NCT05452772
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
Tobacco Use Disorder · Johns Hopkins University · Ages 21+
3 sites in United States (Birmingham, Baltimore, New York)
In Maryland: Johns Hopkins University School of Medicine, Baltimore
- RecruitingPhase 2NCT06067737
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
Opioid Use Disorder · Johns Hopkins University · Ages 21 to 70
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 1NCT06355414
Psilocybin in Chronic Low Back Pain and Depression
Chronic Low-back Pain, Depression · Johns Hopkins University · Ages 21 to 80
Baltimore, Maryland, United States
In Maryland: Johns Hopkins University School of Medicine, Baltimore
- RecruitingEarly phase 1NCT06656702
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 1NCT06660381
Psilocybin-assisted Treatment for Cannabis Use Disorder
Cannabis Use Disorder · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 1NCT06772753
Investigation of Psychedelic Effects in Psychoactive Substances
Psychedelic Effects in Healthy Volunteers · Johns Hopkins University · Ages 25 to 55
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 3NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder · Cybin IRL Limited · Ages 18 to 85
79 sites in 8 countries
In Maryland: Johns Hopkins Medicine, Baltimore; Sunstone Medical, PC, Rockville
- RecruitingPhase 2NCT06902974
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD
Post Traumatic Stress Disorder, PTSD · Sunstone Medical · Ages 18+
Rockville, Maryland, United States
In Maryland: Sunstone Medical, PC, Rockville
- RecruitingPhase 1NCT06989957
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder · Johns Hopkins University · Ages 21+
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 1NCT07053917
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
Stroke, Chronic Stroke, Intracerebral Haemorrhage · Johns Hopkins University · Ages 18+
Baltimore, Maryland, United States
In Maryland: Johns Hopkins, Baltimore
- RecruitingPhase 1NCT07180108
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Psilocybin, Music Intervention · Johns Hopkins University · Ages 21 to 75
Baltimore, Maryland, United States
In Maryland: Center for Psychedelics and Consciousness Research in the Behavioral Biology Research Center, Baltimore
- RecruitingEarly phase 1NCT07565493
Psilocybin Administration With 5-HT1a Blockade
Psychedelic Effects in Healthy Volunteers · Johns Hopkins University · Ages 21 to 60
Baltimore, Maryland, United States
In Maryland: Center for Psychedelics and Consciousness Research, Baltimore
- RecruitingPhase 1 / Phase 2NCT07610135
Psilocybin Efficacy With or Without Pimavanserin Pretreatment
Mood (Psychological Function), Well Being, Mood · Johns Hopkins University · Ages 21 to 65
Baltimore, Maryland, United States
In Maryland: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
- RecruitingPhase 2NCT07721467
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Alzheimer's Disease · National Institute on Aging (NIA) · Ages 65 to 120
Baltimore, Maryland, United States
In Maryland: National Institute of Aging, Clinical Research Unit, Baltimore
- Not yet recruitingPhase 1NCT07877987
The Impact of Dose on the Impairing, Intoxicating, and Abuse-Related Effects of Psilocybin
Psilocybin Intoxication · Johns Hopkins University · Ages 21+
Baltimore, Maryland, United States
In Maryland: Johns Hopkins University, Baltimore
How joining a trial works
- Free to take part
- Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.
- Screened first
- Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.
- Eligibility is strict
- Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.
- You may get a placebo
- Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.
- Contact the study team through the registry
- Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.
- Not medical advice
- This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.