Psilocybin trials for substance use (any)

How joining a trial works

Free to take part

Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.

Screened first

Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.

Eligibility is strict

Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.

You may get a placebo

Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.

Contact the study team through the registry

Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.

Not medical advice

This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications

Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.

Other conditions

• Depression
• PTSD
• Anxiety
• Alcohol use disorder
• Opioid use disorder
• Cancer and end-of-life distress
• OCD
• Pain and headache
• Dementia and cognition
• Healthy volunteers