Psilocybin trials for dementia and cognition
5 recruiting now, grouped by the conditions each study lists on ClinicalTrials.gov, read 28 October 2026. Recruiting trials are listed first.
- RecruitingEarly phase 1NCT04123314
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Depressive Symptoms, Depression, Alzheimer Disease · Johns Hopkins University · Ages 18 to 85
Baltimore, Maryland, United States
- RecruitingPhase 2NCT06455293
Psilocybin Therapy for Depression in Parkinson's Disease
Parkinson Disease, Depression · Joshua Woolley, MD, PhD · Ages 40 to 80
San Francisco, California, United States
- RecruitingPhase 2NCT06782724
Psilocybin Therapy for Psychological Distress in Palliative Patients
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis) · University Medical Center Groningen · Ages 18+
4 sites in 4 countries
- RecruitingPhase 2NCT07610369
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
Depression, Parkinson's Disease (PD) · Yale University · Ages 40 to 80
New Haven, Connecticut, United States
- RecruitingPhase 2NCT07721467
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Alzheimer's Disease · National Institute on Aging (NIA) · Ages 65 to 120
Baltimore, Maryland, United States
How joining a trial works
- Free to take part
- Trials generally cost participants nothing for the study drug and the study visits, and some pay for travel or time. Check what a study covers on its registry page.
- Screened first
- Every study screens volunteers with questionnaires, medical history and often a physical and psychiatric check. Many people who apply are not enrolled.
- Eligibility is strict
- Common exclusions include a personal or family history of psychosis or bipolar disorder, some heart conditions, pregnancy and certain medications, which you may be asked to stop under medical supervision. Never stop a medication on your own to qualify.
- You may get a placebo
- Many trials compare psilocybin with a placebo or a low dose, and you may not be told which you had until the study ends.
- Contact the study team through the registry
- Each registry record lists the study contacts and sites. We do not republish personal emails or phone numbers; use the link on each trial page.
- Not medical advice
- This is a list of registry records, not a recommendation. Talk to your doctor before applying. Disclaimer · Safety and medications
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine, read 28 October 2026. Filter: overall status RECRUITING or NOT_YET_RECRUITING; an intervention named psilocybin, psilocin, COMP360 or CYB003. Refreshed weekly; a study's own registry page is always the current record.