Psilocybin law in Czech Republic
Medical or authorised prescribing Checked 11 October 2026
From 1 January 2026 Czech law allows psilocybin as a medicine, given by a psychiatrist under supervision in Ministry of Health psychiatric hospitals and hospital psychiatric departments, for adults with specified depression indications. Retreat or recreational use remains illegal.
A doctor or psychiatrist may give or prescribe psilocybin to patients under a medical programme or a case-by-case authorisation. It is not open to retreats or adult use. A summary of published sources, not legal advice.
What the sources say
- Act No. 270/2025 Coll. (promulgated 5 August 2025; the psilocybin provisions in force from 1 January 2026) amended Act 167/1998 on Addictive Substances (new s.3(3) and s.33l) and the Medicines Act 378/2007 (s.79a). Psilocybin for medical use may be used only in psychiatric hospitals and hospital psychiatric departments directly managed by the Ministry of Health and licensed by it, given by a psychiatrist (or a specialist in medical psychotherapy) who supervises the session, only in justified cases to patients over 18, following the clinical guideline. The indications are set by government regulation. [Zakon c. 270/2025 Sb. (cl. XV, zmena zakona o navykovych latkach; cl. XXIX, zmena zakona o lecivech), e-Sbirka, Ministry of the Interior of the Czech Republic, 2025-08-05, read 11 October 2026]
- The Czech Psychiatric Society guideline, citing the government regulation, limits treatment to cases where registered medicines have failed or are not tolerated, in three indications: depression associated with cancer, clinically severe depression with documented failure of prior treatment, and other severe disorders that acutely threaten life where usual treatment fails. [Lecba psilocybinem - Doporucene postupy psychiatricke pece, Czech Psychiatric Society, read 11 October 2026]
Dated changes
- 1 January 2026: The psilocybin provisions of Act No. 270/2025 Coll. took effect. Psilocybin for medical use may be given only by a psychiatrist, under supervision, to patients over 18 in Ministry of Health psychiatric hospitals and hospital psychiatric departments licensed by the Ministry. The clinical guideline limits it to depression associated with cancer, clinically severe depression where prior treatment failed, and other severe life-threatening disorders where usual treatment fails. Retreat and recreational use remain illegal. Source
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